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5c–d). CX-5461-mediated S33 phosphorylation of RPA was unbiased on the cell cycle phase and was not limited to your nucleoli in HR-deficient cells. Consequently, the development of ssDNA buildings in CX-5461 dealt with cells can cause replication fork stalling and ATR activation with HRD exacerbating CX-5461-mediated replication strain and this